Publications in Biomolecular Research

The Laboratory of Biomolecular Research - consisting of the groups Structural Biology: Membrane Proteins, Structural Biology: Protein Interactions and Molecular Cell Biology - is primarily engaged in basic research projects. The combination of these two activities provides an attractive environment for research aiming to establish structure-function relationships for biomolecular systems.

2010

Dell'Era Dosch, D. and Ballmer-Hofer, K.
Transmembrane domain-mediated orientation of receptor monomers in active VEGFR-2 dimers.
FASEB J. 24(1), 32 -38 (2010).

2009

Berger,P., Tersar,K., Ballmer-Hofer, K., and Suter, U. (2009).
The CMT4B disease-causing proteins MTMR2 and MTMR13/SBF2 regulate AKT signaling.
J Cell Mol Med. 2009 Nov 13. [Epub ahead of print]

Friedli,A., Fischer, E., Novak-Hofer, I., Cohrs, S., Ballmer-Hofer, K., Schubiger, P.A., Schibli, R., and Grunberg, J.
The soluble form of the cancer-associated L1 cell adhesion molecule is a pro-angiogenic factor.
Int. J. Biochem. Cell Biol. 41, 1572-1580 (2009)

Gruenewald,F.S., Prota,A.E., Giese,A., and Ballmer-Hofer,K.
Structure-function analysis of VEGF receptor activation and the role of coreceptors in angiogenic signaling.
Biochim Biophys Acta. 2009 Sep 15. [Epub ahead of print] (2009)

Li, X.D., Huergo L.F., Gasperina A. Pedrosa F.O., Merrick M., and Winkler F.K.
Crystal structure of dinitrogenase reductase activating glycohydrolase (DRAG) reveals conservation in the ADP-ribosylhydrolase fold and specific features in the ADP-ribose binding pocket.
J. Mol. Biol. 390, 737 - 746 (2009)

Stuttfeld, E. and Ballmer-Hofer, K.
Structure and function of VEGF receptors. IUBMB.
Life 61, 915-922 (2009)

Tremmel, M., Matzke, A., Albrecht, I., Laib, A.M., Olaku, V., Ballmer-Hofer, K., Christofori, G., Heroult, M., Augustin, H.G., Ponta, H., and Orian-Rousseau,V.
A CD44v6 peptide reveals a role of CD44 in VEGFR-2 signaling and angiogenesis.
Blood 114, 5236 - 5244 (2009)

Lingaraju G.M., Prota A.E., Winkler F.K.
Mutational studies of Pa-AGOG DNA glycosylase from the hyperthermophilic crenarchaeon Pyrobaculum aerophilum.
DNA Repair (Amst). 8, 857 -864 (2009)

Schulz, B., Stirnimann, C.U., Grimshaw, J.P.A., Brozzo, M.S., Fritsch F., Mohorko, E., Capitani, G., Glockshuber, R., Grütter, M.G. and Aebi, M.
Oxidoreductase activity of oligosaccharyltransferase subunits Ost3p and Ost6p defines site-specific glycosylation efficiency
Proc. Natl. Acad. Sci. USA 106, 11061 - 11066 (2009)

Honnappa, S., Montenegro Gouveia, S., Weisbrich, A., Damberger, F.F., Bhavesh, N.S., Jawhari, H., Grigoriev, I., van Rijssel, F.J.A., Buey, R.M., Lawera, A., Jelesarov, I., Winkler, F.K., Wüthrich, K., Akhmanova, A. and Steinmetz, M.O.
An EB1-binding motif acts as a microtubule tip localization signal.
Cell 138, 366 - 376 (2009)

Nie, Y., Bieniossek, C., Frey, D., Olieric, N., Schaffitzel, C., Steinmetz, M.O. and Berger, I.
ACEMBLing multigene expression vectors by recombineering.
Nat. Protoc., in press (2009)

Manna, T., Thrower, D.A., Honnappa, S., Steinmetz, M.O. and Wilson, L.
Regulation of Microtubule Dynamic Instability in vitro by Differentially Phosphorylated Stathmin.
J. Biol. Chem. 284, 15640-15649 (2009)

Wasmer, C., Benkemoun, L., Sabaté, R., Steinmetz, M.O., Coulary-Salin, B., Wang, L., Riek, R., Saupe, S. and Meier, B.H.
Solid-State NMR reveals that E. coli inclusion bodies of HET-s(218-289) are amyloids.
Angew. Chem. Int. Ed. Engl. 48, 4858-4860 (2009)

Bieniossek, C., Nie, Y., Frey, D., Olieric, N., Schaffitzel, C., Collinson, I., Romier, C., Berger, P., Richmond, T.J., Steinmetz, M.O.* and Berger, I.*
Automated unrestricted multigene recombineering for multiprotein complex production.
Nat. Methods 6, 447 - 450 (2009)

Komarova, Y., De Groot, C.O., Grigoriev, I., Montenegro Gouveia, S., Munteanu, L., Schober, J.M., Honnappa, S., Buey, R.M., Hoogenraad, C.C., Dogterom, M., Borisy, G.G., Steinmetz, M.O. and Akhmanova, A.
Mammalian EB proteins control persistent microtubule growth.
J. Cell Biol. 184, 691-706 (2009).

2008

Steinmetz, M.O., Akhmanova, A.
Capturing protein tails by CAP-Gly domains.
Trends Biochem. Sci. 33, 535 - 545 (2008)

Weichel M., Jaussi R., Rhyner C., Crameri R.
Display of E. coli Alkaline Phosphatase pIII or pVIII Fusions on Phagemid Surfaces Reveals Monovalent Decoration with Active Molecules.
The Open Biochemistry Journal 2, 38 - 43 (2008)

Hwang, S.J., Kim, S.H., Kim, H.Z., Steinmetz, M.O., Koh, G.Y. and Lee, G.M.
High-level Expression and Purification of a Designed Angiopoietin-1 Chimeric Protein, COMP-Ang1, Produced in Chinese Hamster Ovary Cells.
Protein J. 27, 319 - 326 (2008).

Narzi D., Siu S.W., Stirnimann C.U., Grimshaw J.P., Glockshuber R., Capitani G., Böckmann R.A.
Evidence for proton shuffling in a thioredoxin-like protein during catalysis.
J. Mol. Biol. 382, 978 - 986 (2008)

Grimshaw J.P., Stirnimann C.U., Brozzo M.S., Malojcic G., Grütter M.G., Capitani G., Glockshuber R.
DsbL and DsbI form a specific dithiol oxidase system for periplasmic arylsulfate sulfotransferase in uropathogenic Escherichia coli.
J. Mol. Biol. 380, 667 - 680 (2008)

Vacca R.A., Giannattasio S., Capitani G., Marra E., Christen P.
Molecular evolution of B6 enzymes: binding of pyridoxal-5'-phosphate and Lys41Arg substitution turn ribonuclease A into a model B6 protoenzyme.
BMC Biochem. 9, 17 (2008)

Mukhopadhyay D., Howell K.S., Riezman H., Capitani G.
Identifying key residues of sphinganine-1-phosphate lyase for function in vivo and in vitro.
J. Biol. Chem. 283, 20159-20169 (2008)

Puorger C., Eidam O., Capitani G., Erilov D., Grütter M.G., Glockshuber R.
Infinite kinetic stability against dissociation of supramolecular protein complexes through donor strand complementation.
Structure 16, 631 - 642 (2008)

Eidam O., Dworkowski F.S., Glockshuber R., Grütter M.G., Capitani G.
Crystal structure of the ternary FimC-FimF(t)-FimD(N) complex indicates conserved pilus chaperone-subunit complex recognition by the usher FimD.
FEBS Lett. 582, 651 - 655 (2008)

Azzaroni O., Mir M., Tiefenauer L., Knoll W.
Electrochemical rectification with redox-labeled supramolecular bioconjugates: molecular building blocks fort he construction of biodiodes
Langmuir 24, 2878 -2883 (2008)

Tiefenauer, L. , Studer, A.
Nano for Bio: Nanopore arrays for stable and functional lipid bilayer membranes
Biointerphases 3, FA74-FA79 (2008)

Mir, M., Álvarez, M. , Azzaroni, O., Tiefenauer, L., Knoll, W.
Molecular architectures for electrocatalytic amplification of oligonucleotide hybridization.
Anal. Chem. 80, 6554 - 6559 (2008)

Rennel, E.S., Hamdollah-Zadeh, M.A., Wheatley, E.R., Magnussen, A., Schuler, Y., Kelly, S.P., Finucane, C., Ellison, D., Cebe-Suarez, S., Ballmer-Hofer, K., Mather, S., Stewart, L., Bates, D.O., and Harper, S.J.
Recombinant human VEGF(165)b protein is an effective anti-cancer agent in mice.
Eur. J. Cancer 44, 1883 - 1894 (2008)

Kawamura,H., Li, X., Goishi,K., van Meeteren,L.A., Jakobsson,L., Cebe-Suarez,S., Shimizu,A., Edholm,D., Ballmer-Hofer,K., Kjellen,L., Klagsbrun,M., and Claesson-Welsh,L.
Neuropilin-1 in regulation of VEGF-induced activation of p38MAPK and endothelial cell organization.
Blood 112, 3638 - 3649 (2008)

Cébe-Suarez, S., Grunewald, F.S., Jaussi, R., Li, X., Claesson-Welsh, L., Spillmann, D., Mercer, A.A., Prota, A.E., and Ballmer-Hofer, K.
Orf virus VEGF-E NZ2 promotes paracellular NRP-1/VEGFR-2 coreceptor assembly via the peptide RPPR.
FASEB J. 22: 3078-3086 (2008)

Soro,S., Orecchia,A., Morbidelli,L., Lacal,P.M., Morea,V., Ballmer-Hofer,K., Ruffini,F., Ziche,M., D'Atri,S., Zambruno,G., Tramontano,A., and Failla,C.M.
A proangiogenic peptide derived from vascular endothelial growth factor receptor-1 acts through {alpha}5{beta}1 integrin.
Blood 111, 3479 - 3488 (2008)

Licht K, Medenbach J, Lührmann R, Kambach C, Bindereif A.
3'-cyclic phosphorylation of U6 snRNA leads to recruitment of recycling factor p110 through LSm proteins.
RNA 14,1532 - 1538 (2008)

Dolenc, J., Baron, R., Missimer, J.H., Steinmetz, M.O. and van Gunsteren, W.F.
Exploring the conserved water sites and hydration of a coiled-coil trimerization motif: A MD simulation study.
Chembiochem. 9, 1749 - 1756 (2008)

Verel, R., Tomka, I.T., Bertozzi, C., Cadalbert, R., Kammerer, R.A., Steinmetz, M.O. and Meier, B.H.
Polymorphism in an amyloid-like fibril forming model peptide.
Angew. Chem. 47, 5842 - 5845 (2008)

Akhmanova, A., Steinmetz, M.O.
Traking the ends: a dynamic protein network controls the fate of microtubule tips.
Nat. Rev. Mol. Cell Biol. 9, 309 - 322 (2008)

Javelle A., Lupo D., Ripoche P., Fulford T., Merrick M., Winkler F.K.
Substrate binding, deprotonation, and selectivity at the periplasmic entrance of the Escherichia coli ammonia channel AmtB.
Proc Natl Acad Sci USA, 105, 5040 -5045 (2008)

Grigoriev, I., Montenegro Gouveia, S., van der Vaart, B., Demmers, J., Smyth, J.T., Honnappa, S., Splinter, D., Steinmetz, M.O., Putney, J.W., Hoogenraad, C.C., Akhmanova, A.
STIM1 is a MT-plus-end-tracking protein involved in remodeling of the ER.
Curr. Biol. 18, 177 - 182 (2008)

2007

Zehnder-Fjällman, A.H.M., Marty, C., Halin, C., Hohn, A., Schibli, R., Ballmer-Hofer, K., and Schwendener, R.A. Evaluation of anti-VEGFR-3 specific scFv antibodies as potential therapeutic and diagnostic tools for tumor lymph-angiogenesis Oncology Reports 18: 933-941 (2007)

Ruch,C., Skiniotis,G., Steinmetz,M.O., Walz,T., andBallmer-Hofer,K. Structure of a VEGF / VEGF-receptor complex
as determined by EM. Nature Structural & Molecular Biology 14: 249-250 (2007)

Bergman N., Moraes K.C., Anderson J.R., Zaric B., Kambach C., Schneider R.J., Wilusz C.J., Wilusz J.
LSm proteins bind and stabilize RNAs containing 5' poly(A) tracts.
Nat Struct Mol Biol. 14(9):824 - 831 (2007)

Javelle, A., Lupo, D., Li, X.D., Merrick, M. Chami, M. Ripoche, P. Winkler, F.K.
Structural and Mechanistic Aspects of Amt/Rh Proteins.

J. Struct. Biol. 158, 472 - 481 (2007)

Han X., Studer A., Sehr H., Geissbühler I., Di Berardino M., Winkler F.K., Tiefenauer L.X.
Nanopore Arrays for Stable and Functional Free-Standing Lipid Bilayers.
Adv. Mater., 19, 4466 - 4470 (2007)

Lupo D.,  Li X.D., Durand A., Tomizaki T., Cherif-Zahar B., Matassi G., Merrick M., Winkler F.K.

The 1.3-Å resolution structure of Nitrosomonas europaea Rh50 and mechanistic implications for NH₃ transport by Rhesus family proteins.
Proc. Natl. Acad. Sci. USA, 104 (49), 19303 - 19308 (2007)

Teuling, E., Ahmed, S., Haasdijk, E., Demmers, J., Steinmetz, M.O., Akhmanova, A., Jaarsma, D., Hoogenraad, C.C.
Motor neuron disease-associated mutant VAPB recruits wild type VAPs into ER-derived tubular aggregates.
J. Neursci., 27, 9801 - 9815 (2007)
 

Weisbrich, A., Honnappa, S., Jaussi, R., Okhrimenko, O., Frey, D., Jelesarov, I., Akhmanova, A., Steinmetz, M.O.
Structure-function relationship of CAP-Gly domains.
Nat. Struct. Mol. Biol., 14, 959 - 967 (2007)

Scherr, N., Honnappa, S., Kunz, G., Mueller, P., Jayachandran, R., Winkler, F.K., Pieters, J., Steinmetz, M.O.
Structural Basis for the specific inhibition of protein kinase G, a virulence factor of Mycobacterium tuberculosis.
Proc. Natl. Acad. Sci. USA, 104, 12151 - 12156 (2007)

Koller-Eichhorn R., Marquardt T., Gail R., Wittinghofer A., Kostrewa D., Kutay U., Kambach C.
Human OLA1 defines an ATPase subfamily in the OBG family of GTP-binding proteins.
J. Biol. Chem. 282, 19928 -19937 (2007)

Frey, D., Kambach, C., Steinmetz, M.O., Jaussi, R.
Production of in vitro amplified DNA pseudolibraries and high-throughput cDNA target amplification.
BMC Biotechnology, 7, 31 (2007).

John, C.M., Hite, R.K., Weirich, C.S., Fitzgerald, D.J., Faty, M., Jawhari, H., Schlaepfer, D., Kroschewski, R., Winkler, F.K., Barral, Y., Steinmetz, M.O.
The Caenorhabditis elegans septin complex is non-polar.
EMBO J., 26, 3296 - 3307 (2007)

Missimer, J.H., Steinmetz, M.O., Baron, R., Winkler, F.K., Kammerer, R.A., Daura, X., van Gunsteren, W.F.
Configurational entropy elucidates the role of salt-bridge networks in protein thermostability.
Prot. Sci. 16, 1349 - 1359 (2007)

Steinmetz, M.O., Jelesarov, I., Matousek, W.M., Honnappa, S., Jahnke, W., Missimer, J.H., Frank, S., Alexandrescu, A.T.,
Kammerer, R.A.
Molecular basis of coiled-coil formation.
Proc. Natl. Acad. Sci. USA 104, 7062-7067 (2007)

Ruch C., Skiniotis G., Steinmetz M.O., Walz T., Ballmer-Hofer K.
Structure of a VEGF / VEGF-receptor complex as determined by EM.
Nat. Struct. Mol. Biol.14, 249-250 (2007)

Tiefenauer L.X.
Magnetic nanoparticles as contrast agents for medical diagnosis.
Chapt. 29 in: “Nanotechnology in biology and medicine, methods devices, and applications”, T. Vo-Dinh (ed.),
CRC Press, Taylor & Francis, p. 1 - 20 (2007).

Studer R., Dahinden P., Wang W.-W., Auchli Y., Li X.-D., Dimroth P.
Crystal structure of the carboxyltransferase domain of the oxaloacetate
decarboxylase Na+ pump from Vibrio cholerae.
J. Mol. Biol. 367, 547 - 557 (2007)

Steinmetz M.O.
Structure and thermodynamics of the tubulin-stathmin interaction.
J. Struct. Biol.158, 137 - 147 (2007)

Conroy M.J., Durand A., Lupo D., Li X.D., Bullough P.A., Winkler F.K., Merrick M.
The crystal structure of the Escherichia coli AmtB-GlnK complex reveals how GlnK regulates the ammonia channel.
Proc. Natl. Acad. Sci. USA 104(4), 1213 - 1218 (2007)

2006

Wang P., Palfi Z., Preusser C., Lücke S., Lane W.S., Kambach C., Bindereif A.
Sm core variation in spliceosomal small nuclear ribonucleoproteins from Trypanosoma brucei.
EMBO J. 25(19):4513 - 4523 (2006)

Javelle A., Lupo D., Zheng L., Li X.D., Winkler F.K., Merrick M.
An unusual twin-his arrangement in the pore of ammonia channels is essential for substrate conductance.
J. Biol. Chem. 281 (51), 39492 - 39498 (2006)

Wagner A., Pieren M., Schulze-Briese C., Ballmer-Hofer K., Prota, A.E.
Structure Determination of VEGF-E by Sulfur-SAD.
Acta Cryst. D62, 1430 - 1434 (2006).

Cébe-Suarez S., Pieren M., Cariolato L., Arn S., Hoffmann U., Bogucki A., Manlius C., Wood J., Ballmer-Hofer K.
A VEGF-A splice variant defective for heparan sulfate and neuropilin-1 binding shows attenuated signaling through VEGFR-2.
Cellular and Molecular Life Sciences (CMLS) 63, 2067 - 2077 (2006)

Liu J., Tiefenauer L., Tian S., Nielsen P.E., Knoll W.
Study on PNA-DNA hybridization based on labeled-streptavidin by voltammetry and surface plasmon fluorescence spectroscopy.
Anal. Chem. 78, 470 - 476 (2006)

Cébe-Suarez S., Zehnder-Fjallman A., Ballmer-Hofer K.
The role of VEGF receptors in angiogenesis; complex partnerships.
CMLS 63, 601 - 615 (2006)

Marty C., Langer-Machova Z., Sigrist S., Schott H., Schwendener R.A., Ballmer-Hofer K.
Isolation and characterization of a scFv antibody specific for tumor endothelial marker 1 (TEM1), a new reagent for targeted tumor therapy.
Cancer Lett. 235, 298 - 308 (2006)

Zeisberger S.M., Odermatt B., Marty C., Zehnder-Fjallman A.H., Ballmer-Hofer K., and Schwendener R.A.
Clodronate-liposome-mediated depletion of tumour-associated macrophages: a new and highly effective antiangiogenic therapy approach.
Br. J. Cancer. 7: 272 - 281 (2006)

Brem F., Tiefenauer L., Fink A., Dobson J., Hirt A. M.
A mixture of ferritin and magnetite nanoparticles mimics magnetic properties of human brain tissue
Phys. Rev. B 73, 224427, 1 - 6 (2006)

Macdonald P.R., Progias P., Ciani B., Patel S., Mayer U., Steinmetz M.O., Kammerer R.A.
Structure of the Extracellular Domain of Tie Receptor Ttyrosine Kinases and Localization of the Angiopoietin-Binding Epitope.
J. Biol. Chem.281, 28408 - 28414 (2006)

Honnappa, S., Okhrimenko, O., Jaussi, R., Jawhari, H., Jelesarov, I., Winkler, F.K., and Steinmetz, M.O.
Key interaction modes of dynamic +TIP networks.
Mol. Cell 23:663-671 (2006)

Honnappa S., Jahnke W., Seelig J., Steinmetz M.O.
Control of Intrinsically Disordered Stathmin by Multisite Phosphorylation.
J. Biol. Chem. 281, 16078 - 16083 (2006)

Kammerer R.A., Steinmetz M.O.
De Novo Design of a Two-Stranded Coiled-Coil Switch Peptide.
J. Struct. Biol. 155, 146 - 153 (2006)

Li XD, Lupo D, Zheng L, Winkler F.
Structural and Functional Insights into the AmtB/Mep/Rh Protein Family.
Transfus. Clin. Biol. 13, 65 - 69 (2006).

Pieren M., Prota A.E., Ruch C., Kostrewa D., Wagner A., Biedermann K., Winkler F.K., Ballmer-Hofer K.
Crystal Structure of the Orf Virus NZ2 Variant of Vascular Endothelial Growth Factor-E. Implications for Receptor Specificity.
J. Biol. Chem. 281(28): 19578 - 19587 (2006)

Winkler F.K.
Amt/MEP/Rh Proteins Conduct Ammonia.
Pflugers Arch. 451, 701 - 707 (2006)

Siemer A.B., Ritter C., Steinmetz M.O., Ernst M., Riek R., Meier B.H.
13C, 15N Resonance Assignment of Parts of the HET-s Prion Protein in its Amyloid Form.
J. Biomol. NMR 34, 75 - 87 (2006)

2005

Azzouz T.N., Pillai R.S., Däpp C., Chari A., Meister G., Kambach C., Fischer U., Schümperli D.
Toward an assembly line for U7 snRNPs: interactions of U7-specific Lsm proteins with PRMT5 and SMN complexes.
J Biol Chem. 280, 34435 -34440 (2005)

Simultaneously amplified electrochemical and surface plasmon resonce optical detection of DNA hybridization based on ferrocene-streptavidin conjugates.
Liu J., Tian S., Tiefenauer L., Nielson P.E. Knoll W.
Anal. Chem. 77, 2756 - 2761 (2005)

Xu H., Pillai R.S., Azzouz T.N., Shpargel K.B., Kambach C., Hebert M.D., Schümperli D., Matera A.G.
The C-terminal domain of coilin interacts with Sm proteins and U snRNPs.
Chromosoma 114, 155 - 166 (2005)

Marquardt T., Kostrewa D., Balakrishnan R., Gasperina A., Kambach C., Podjarny A., Winkler F.K., . Balendiran G.K, Li X.-D.
High Resolution Crystal Structure of AKR11C1 from Bacillus halodurans: A NADPH-Dependent 4-Hydroxy-2,3-Trans-Nonenal Reductase.
J Mol Biol. 354, 304 - 316 (2005)

Missimer J.H., Steinmetz M.O., Jahnke W., Winkler F.K., van Gunsteren W.F., Daura X.
Molecular-Dynamics Simulations of C- and N-Terminal Peptide Derivatives of GCN4-p1 in Aqueous Solution.
Chemistry & Biodiversity 2, 1086 - 1104 (2005).

Kostrewa D., Winkler F.K., Folkers G., Scapozza L., Perozzo R.
The Crystal Structure of PfFabZ, the Unique beta-Hydroxyacyl-ACP Dehydratase Involved in Fatty Acid Biosynthesis of Plasmodium falciparum.
Protein Sci. 14, 1570 - 1580 (2005)

Zaric B., Chami M., Remigy H., Engel A., Ballmer-Hofer K., Winkler F.K., Kambach C.
Reconstitution of Ttwo Recombinant LSm Protein Complexes Reveals Aspects of Their Architecture, Assembly, and Function.
J. Biol. Chem. 280(16):16066-16075 (2005)

Kammerer, R.A., Kostrewa, Progias, P., Honnappa, S., D., Avilla, D., Lustig A., Winkler, F.K., Pieters, J. and Steinmetz, M.O.
A Conserved Trimerization Motif Controls the Topology of Short Coiled Coils.
Proc. Natl. Acad. Sci. USA 102(39): 13891-13896 (2005)

Gigant B., Wang C., Ravelli R.B., Roussi F., Steinmetz M.O., Curmi P.A., Sobel A., Knossow M.
Structural Basis for the Regulation of Tubulin by Vinblastine.
Nature 435(7041), 519-522 (2005)

Lingaraju G.M., Sartori A.A., Kostrewa D., Prota A.E., Jiricny J., Winkler F.K.
A DNA Glycosylase from Pyrobaculum aerophilum with an 8-Oxoguanine Binding Mode and a Noncanonical Helix-Hairpin-Helix Structure.
Structure. 13, 87 - 98 (2005).

Honnappa S., John C.M., Kostrewa D., Winkler F.K., Steinmetz M.O.
Structural Insights Into the EB1-APC Interaction.
EMBO J. 24, 261 - 269 (2005)

2004

Cavalli A., Prota A.E., Stehle T., Dermody T.S., Recanatini M., Folkers G. , Scapozza L.
A Molecular Dynamics Study of Reovirus Attachment Protein sigma 1 Reveals Conformational Changes in sigma 1 Structure.
Biophysical J. 86, 3423 -3431 (2004).

Cho C.H., Kammerer R.A., Lee H.J., Steinmetz M.O.,  Ryu Y.S., Lee S.H., Yasunaga K., Kim K.T., Kim I. , Choi H.H., Kim W., Kim S.H., Park S.K., Lee G.M., Koh G.Y.
COMP-Ang1: A Designed Angiopoietin-1 Variant with Nonleaky Angiogenic Activity.
Proc. Natl. Acad. Sci.USA 101, 5547 - 5552 (2004)

Christen P., Jaussi R.
Lehrbuch: Eine Einführung mit 40 Lerneinheiten Biochemie.
Springer Verlag, Heidelberg, pp 635, ISBN 3-540-21164-0 (2004)

Engler O.B., Schwendener R.A., Dai W.J., Wolk B., Pichler W., Moradpour D., Brunner T., Cerny A.
A Liposomal Peptide Vaccine Inducing CD8+ T Cells in HLA-A2.1 Transgenic Mice, which Recognise Human Cells Encoding Hepatitis C Virus (HCV) Proteins .
Vaccine 23, 58 - 68 (2004)

Eliaz R.E., Nir S., Marty C., Szoka F.C.
Determination and Modeling of Kinetics of Cancer Cell Killing by Doxorubicin and Doxorubicin Encapsulated in Targeted liposomes.
Cancer Res. 64, 711 - 718 (2004)

Kammerer R.A., Kostrewa D., Zurdo J., Detken A., García-Echeverría C., Green J.D., Müller S.A., Meier B.H., Winkler F.K., Dobson C.M., Steinmetz M.O.
Exploring Amyloid Formation by a de novo Design.
Proc. Natl. Acad. Sci. USA 101, 4435 - 4440 (2004)

Marty C., Meylan C., Schott H., Ballmer- Hofer K., Schwendener R.A.
Enhanced Heparan Sulfate Proteoglycan-mediated Uptake of Cell-penetrating Peptide-modified Liposomes.
Cell Mol. Life Sci.61, 1785 - 1794 (2004)

Sartori A.A., Lingaraju G.M., Hunziker P. , Winkler F.K., Jiricny J.
Pa-AGOG, the Founding Member of a New Family of Archaeal 8-Oxoguanine DNA-Glycosylases.
Nucleic Acids Res.32, 6531 - 6539 (2004)

Storni T., Ruedl C., Schwarz K., Schwendener R.A., Renner W.A., Bachmann M.F.
Nonmethylated CG Motifs Packaged into Virus-like Particles Induce Protective Cytotoxic T Cell Responses in the Absence of Systemic Side Effects.
J. Immunol. 172, 1777 - 1785 (2004)

Molecular assembly of redox-conductive ferrocene-streptavidin – towards bioelectrochemical devices.
Padeste C., Steiger B., Grubelnik A., Tiefenauer L.
Biosensors & Bioelectronics 20, 545-552 (2004)

Wergin M.C., Ballmer-Hofer K., Roos M., Achermann R.E., Inteeworn N., Akens M.K., Blattmann H., Kaser-Hotz B.
Preliminary Study of Plasma Vascular Endothelial Growth factor (VEGF) During Low- and High-dose Radiation Therapy of Dogs with Spontaneous Tumors.
Vet. Radiol. Ultrasound 45, 247 - 254 (2004)

Zheng L., Kostrewa D., Berneche S., Winkler F.K., Li X.D.
The Mechanism of Ammonia Transport Based on the Crystal Structure of AmtB of Escherichia coli.
Proc. Natl. Acad. Sci. USA 101, 17090 - 17095 (2004)

Nicholls P., Soulimane T.
The Mixed Valence State of the Oxidase Binuclear Centre: How Thermus thermophilus Cytochrome ba3 Differs from Classical aa3 in the Aerobic Steady State and When Inhibited by Cyanide.
Biochem. Biophys. Acta 1655(1-3): 381-387(2004)

2003

Aichele P., Zinke J., Grode L., Schwendener R.A., Kaufmann S.H., Seiler P.
Macrophages of the Splenic Marginal Zone Are Essential for Trapping of Blood-Borne Particulate Antigen but Dispensable for Induction of Specific T cell Responses.
J. Immunol. 171, 1148 - 1155 (2003)

Autiero M., Waltenberger J., Communi D., Kranz A., Moons L., Lambrechts D., Kroll J., Plaisance S., De Mol M., Bono F., Kliche S., Fellbrich G., Ballmer-Hofer K., Maglione D., Mayr-Beyrle U., Dewerchin M., Dombrowski S., Stanimirovic D., Van Hummelen P., Dehio C., Hicklin D.J., Persico G., Herbert J.M., Communi D., Shibuya M., Collen D., Conway E.M., Carmeliet P.
Role of PlGF in the Intra- and Intermolecular Cross TalkBetween the VEGF Receptors Flt1 and Flk1.
Nat. Med. 9, 936 - 943 (2003)

Bruehlmeier M., Roelcke U., Blaeuenstein P., Missimer J., Schubiger P.A., Locher J.T., Pellikka r., Ametamey S.
Measurement of the Extracellular Space in Brain Tumors Using 76Br-Bromide and PET.
J Nucl Med. 44, 1210 - 1218 (2003)

Console S., Marty C., Garcia-Echeverria C., Schwendener R., Ballmer-Hofer K.
Antennapedia and HIV TAT 'Protein Transduction Domains' Promote Endocytosis of High Mr Cargo Upon Binding to Cell Surface Glycosaminoglycans.
J. Biol. Chem. 278(37): 35109-35114 (2003)

Griffin S., Higgins C.L., Soulimane T., Wittung-Stafshede P.
High Thermal and Chemical Stability of Thermus thermophilus Seven-Iron Ferredoxin.
Eur. J. Biochem. 270, 4736 - 4743 (2003)

Heyderman L.J., Ketterer B., Bächle D., Glaus F., Haas B., Schift H., Vogelsang K., Gobrecht J., Tiefenauer L., Dubochet O., Surbled P., Hessler T.
High Volume Fabrication of Customized Nanopore Membrane Chips.
Microelec. Engineering 67-68, 208 - 213 (2003)

Honnappa S., Cutting B., Jahnke W., Seelig J., Steinmetz M.O.
Thermodynamics of the Op18/Stathmin-Tubulin Interaction.
J. Biol. Chem. 278, 38926 - 38934 (2003)

Koutsoupakis K., Stavrakis S., Soulimane T., Varotsis C.
Oxygen-linked Equilibrium CuB-CO Species in Cytochrome ba3-Oxidase from Thermus thermophilus: Implications for an Oxygen Channel at the CuB Site.
J. Biol. Chem. 278,14893 - 14896 (2003)

Koutsoupakis C., Soulimane T., Varotsis C.
Docking Site Dynamics of ba3-Cytochrome c Oxidase from Thermus thermophilus.
J. Biol. Chem. 278, 36805 - 36809 (2003)

Koutsoupakis C., Soulimane T., Varotsis C.
Ligand Binding in a Docking Site of Cytochrome c Oxidase: A Time-Resolved Step-Scan Fourier Transform Infrared Study.
J. Am. Chem. Soc. 125, 14728 - 14732 (2003)

Lemieux M.J., Song J., Kim M.J., Y.Huang, Villa A., Auer M., Li X.D., Wang D.N.
Three-Dimensional Crystallization of the Escherichia coli Glycerol-3-Phosphate Transporter: A Member of the Major Facilitator Superfamily.
Protein, Sci. 12, 2748 -2756 (2003)

Madjdpour C., Jewell U.R., Kneller S., Ziegler U., Schwendener R., Booy C., Klausli L., Pasch T., Schimmer R.C., Beck-Schimmer B.
Decreased Alveolar Oxygen Induces Lung Inflammation.
Am. J. Physiol. Lung Cell. Mol. Physiol. 284(2): L360-L367 (2003)

Martin-Soelch C., MissimerJ., Leenders K.L., Schultz W.
Neural Activity Related to the Processing of Increasing Monetary Reward in Smokers and Nonsmokers.
Eur. J. Neurosci. 18, 680 - 688 (2003)

Novak-Hofer I., Honer M., Ametamey S., Grunberg J., Missimer J., Zimmermann K., Schubiger P.A.
Imaging of Renal Carcinoma Xenografts with 64Cu-Labelled Anti-L1-CAM Antibody chCE7.
Eur. J. Nucl. Med. Mol. Imaging 30, 1066 (2003)

Padeste C., Steiger B., Grubelnik A., Tiefenauer L.
Redox Labeled Avidin for Enzyme Sensor Architectures.
Biosensors & Bioelectronics 19, 239 - 247 (2003)

Prajapati R.S., Lingaraju G.M., Bacchawat K., Surolia A., Varadarajan R.
Thermodynamic Effects of Replacements of Proline Residues in Helix Interiors of Maltose-Binding Protein.
Proteins 53, 863 - 871 (2003)

Prota A.E., Campbell J.A., Schelling P., Forrest J.C., Watson M.J., Peters T.R., Aurrand-Lions M., Imhof B.A., Dermody T.S., Stehle T.
Crystal Structure of Human Junctional Adhesion Molecule 1: Implications for Reovirus Binding.
Proc. Natl. Acad. Sci. USA 100, 5366 - 5371 (2003)

Rubio Demirovic A., Canadi J., Weiglhofer W., Scheidegger P., Jaussi R., Ballmer-Hofer K.
HIV TAT basic peptide is not a high-affinity ligand for VEGF receptor 2.
Biol. Chem. 384, 1435 - 1441 (2003)

Steiger B., Padeste C., Grubelnik A., Tiefenauer L.
Charge Transport Effects in Ferrocene-Streptavidin Multilayers Immobilized on Electrode Surfaces.
Electrochimica Acta 48, 761 - 769 (2003)

Travaglini-Allocatelli C., Gianni S., Morea V., Tramontano A., Soulimane T., Brunori M.
Exploring the Cytochrome c Folding Mechanism: Cytochrome c552 Folds Through an On-Pathway Intermediate.
J. Biol. Chem. 278, 41136 - 41140 (2003)

Wang D.N., Safferling M., Lemieux M.J., Griffith H., Chen Y., Li X.D.
Practical Aspects of Overexpressing Bacterial Secondary Membrane Transporters for Structural Studies.
Biochim Biophys Acta 1610, 23-36 (2003)

Winkler F.K. , Prota A.E.
Structure and Function of EcoRV Endonuclease.
In Pingoud, A. (ed.), Restriction Endonucleases. Nucleic Acids and Molecular Biology, Springer Verlag, Berlin Heidelberg New York, 179-214 (2003)

2002

Bueno da Costa M.H., Quintillio W., Tanizaki M.M., Sant’anna O.A., Schwendener R.A., De Araujo P.S.
Heat Shock Protein Micro-Encapsulation as a Double Tool for the Improvement of New Generation Vaccines.
J. Liposome Res. 12, 29 - 35 (2002)

Chappell J.D.,  Prota A.E., Dermody T.S. , Stehle T. 
Crystal Structure of Reovirus Attachment Protein s1 Reveals Evolutionary Relationship to Adenovirus Fiber.
EMBO J. 21, 1 - 11 (2002)

Hellwig P., Soulimane T., Mäntele W.
Electrochemical, FTIR and UV/VIS Spectroscopic Properties of the caa3 Oxidase from Thermus thermophilus.
Eur. J. Biochem. 269, 4830 - 4838 (2002)

KoutsoupakisK., Stavrakis S., Pinakoulaki E., Soulimane T., Varotsis C.
Observation of the Equilibrium CuB-CO Complex andFunctional Implications of the Transient Heme a3 Propionates in Cytochrome ba3-CO from Thermus thermophilus: FTIR and Time-Resolved Dtep-Scan FTIR Studies.
J. Biol. Chem. 277, 32860 - 32866 (2002)

Lampidis R., Kostrewa D., Hof H.
Molecular Characterization of the Genes Encoding DNA Gyrase and Topoisomerase IV of Listeria monocytogenes.
J. Antimicrob. Chemother. 49, 917 - 924 (2002)

Ludwig P.S., Schwendener R.A., Schott H.
A New Laboratory Scale Synthesis for the Anticancer Drug 3’-C-Etynylcytidine.
Synthesis 16, 2387 - 2392 (2002)

Marty C., Ballmer-Hofer K., Neri D., Klemenz R., Schott H., Schwendener R.A.
Cytotoxic Targeting of F9 Teratocarcinoma Tumours with Anti-ED-B Fibronectin scFv Antibody Modified Liposomes.
Br. J. Cancer 87, 106 - 112 (2002)

Pinakoulaki E., Soulimane T., Varotsis C.
FTIR and Step-Scan Time-Resolved FTIR Spectroscopies Reveal a Unique Active Site in Cytochrome caa3 Oxidase from Thermus thermophilus.
J. Biol. Chem. 277, 32867 - 32874 (2002)

Prota A.E., Sage D., Stehle T., Fingeroth J.
The Crystal Structure of Human CD21: Implications for Epstein-Barr Virus and C3d Binding.
Proc. Natl. Acad. Sci. USA 99, 10641 - 10646 (2002)

Schwendener R.A., Zeisberger S.M.
Targeting of Single-Chain Antibody-Modified Lliposomes for the Iinhibition of Tumor Iinduced Angiogenesis.
Euro-Biotech 2002, 14 - 16 (2002)

Sogabe S., Masubuchi M., Sakata K., Fukami T.A., Morikami K., Shiratori Y., Ebiike H., Kawasaki K., Aoki Y., Shimma N, D'Arcy A., Winkler F.K., Banner D.W., Ohtsuka T.
Crystal Structures of Candida albicans N-Myristoyltransferase with Two Distinct Inhibitors.
Chem. Biol. 9, 1119 - 1128 (2002)

Soulimane T., Kiefersauer R., Than M.E.
ba3-Cytochrome c Oxidase from Thermus thermophilus: Purification, Crystallisation and Crystal Transformation.
Contribution for Academic Press: A Practical Guide to Membrane Protein Purification and Crystallization 229 - 251 (2002)

Tomschy A., Brugger R., Lehmann M., Svendsen A., Vogel K., Kostrewa D., Lassen S.F., Burger D., Kronenberger A., van Loon A.P., Pasamontes L., Wyss M.
Engineering of Phytase for Improved Activity at Low pH.
Appl. Environ. Microbiol. 68, 1907 - 1913 (2002)