G. Capitani, M. Schaerer (Ph.D. student)

Research topics:

·        Structural biology of the type 1 pilus system of uropathogenic Escherichia coli (in collaboration with the Glockshuber group, ETH Zurich)

·        Structural biology of enzymes                                                                                                                                              

·        Structural bioinformatics

Recent publications

40)   Gut H, Dominici P, Pilati S, Astegno A, Petoukhov MV, Svergun DI, Grütter MG & Capitani G (2009)

A Common Structural Basis for pH- and Calmodulin-mediated Regulation in Plant Glutamate Decarboxylase.

J Mol Biol. Jul 4 [Epub ahead of print]

39)  Schulz BL, Stirnimann CU, Grimshaw JP, Brozzo MS, Fritsch F, Mohorko E, Capitani G, Glockshuber R, Grütter MG & Aebi M. (2009)

Oxidoreductase activity of oligosaccharyltransferase subunits Ost3p and Ost6p defines site-specific glycosylation efficiency.

Proc Natl Acad Sci U S A. 106:11061-6

38)  Narzi D, Siu SW, Stirnimann CU, Grimshaw JP, Glockshuber R, Capitani G & Böckmann RA. (2008)

Evidence for proton shuffling in a thioredoxin-like protein during catalysis.

J Mol Biol. 382:978-86

37)  Grimshaw JP, Stirnimann CU, Brozzo MS, Malojcic G, Grütter MG, Capitani G & Glockshuber R. (2008)

DsbL and DsbI form a specific dithiol oxidase system for periplasmic arylsulfate sulfotransferase in uropathogenic Escherichia coli.

J Mol Biol. 380:667-80

36)  Vacca RA, Giannattasio S, Capitani G, Marra E & Christen P. (2008)

Molecular evolution of B6 enzymes: binding of pyridoxal-5'-phosphate and Lys41Arg substitution turn ribonuclease A into a model B6 protoenzyme.

BMC Biochem.  9:17

35)  Mukhopadhyay D, Howell KS, Riezman H & Capitani G. (2008)

Identifying key residues of sphinganine-1-phosphate lyase for function in vivo and in vitro.

J Biol Chem. 283:20159-69

34)  Puorger C, Eidam O, Capitani G, Erilov D, Grütter MG & Glockshuber R. (2008)

Infinite kinetic stability against dissociation of supramolecular protein complexes through donor strand complementation.

Structure. 16:631-42

33)  Eidam O, Dworkowski FS, Glockshuber R, Grütter MG, Capitani G. (2008)

Crystal structure of the ternary FimC-FimF(t)-FimD(N) complex indicates conserved pilus chaperone-subunit complex recognition by the usher FimD.

FEBS Lett. 582:651-5